Spurs manager Jose Mourinho included new signings Matt Doherty and Emile Hojbjerg in the line-up while his opposite number Carlo Ancelotti also named James Rodriguez, Abdoulaye Doucoure and Allan in his line-up.
The English Premier League returns following the international break, with the Merseyside Derby taking center stage on Saturday.
Bafana Bafana ended a tough week with a defeat to Zambia after allowing the visitors to come from behind to win the friendly international 2-1 at the Royal Bafokeng Stadium on Sunday afternoon.
Chelsea were not at their best on Monday evening but just about did enough to edge past Brighton at the Amex to get their 2020/21 Premier League season off to a perfect start.
Kaizer Chiefs were at the summit of the log from August 2019 to September 2020 but it was Mamelodi Sundowns who eventually walked away with the biggest prize in South Africa, securing the league title on the final day of the season.
Dominic Calvert-Lewin nodded the only goal on Sunday as Jose Mourinho's second season at Tottenham started with a 1-0 home defeat to big-spending Everton.